prakriti is related to certain physical and mental tendencies that determine susceptibility to diseases, the ancient texts of Ayurveda also provide guidelines for maintaining lifestyles in accordance with one's prakriti for continued healthy living in a personalized manner. Although numerous publications exist in all the above mentioned topics, on assessing the present literature we felt the need for synthesizing the current state of evidence regarding Ayurvedic prakriti, its relation to metabolism, chronic disease, and genotypes, and the future direction. In this review we have attempted to collate evidence with regards to the relation of prakriti with metabolism, chronic disease and genotypes known so far. We also take this knowledge further to predict a future where it will be possible to screen newborns using their genotype and thus determine their prakriti, which can then help us decide the type of most healthy and suitable lifestyle for such newborns to lead a disease free and productive life. This will be a novel step towards personalized preventive medicine for humans.